Within the Panel, under the Content section, there is a Hotspots tab. Here, you can find every hotspot group you've created in the list view.
In order to go to the Settings page of any Hotspot Group, just click on the gear icon of the corresponding line.
Once you've arrived in the settings page of a particular group, you can alter its current settings starting from its name and continuing with the targeting.
Then, once you're finished, save and click on publish changes to apply these changes to its live version.